Study on the Value of Ultrasound Elastography Combined with Plasma miRNA Expression in the Early Detection of Breast Cancer

Background: Breast cancer (BC) is the most common malignant tumor in women, and its morbidity mortality are increasing each year, due to lack of specific clinical symptoms early stage BC, diagnostic methods for breast cancer. Therefore, identifying an effective method BC has become urgent. Materials Methods: lesions with a histological diagnosis that were examined by ultrasonic elastography (UE) our department from June 2020 December 2021 reviewed. qRT-PCR was performed measure expression levels miR-144-5p miR-26b-5p plasma patients BC. The receiver operating characteristics (ROC) curve area under (AUC) used investigate potential value miR- 144-5p, elastographic score Results: score(UES) found be significantly upregulated compared benign lesions, AUC, sensitivity specificity 0.809, 0.717 0.806 distinguishing respectively. miR-26b- 5p patients, miR-144-5p+miR-26b-5p had 0.781 0.780 Furthermore, we performance combined UES 0.913 0.890 specificity. Conclusions: combination miR-144-5p, very high application detection